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The effect of different concentrations of cerium oxide during pregnancy on ovarian follicle development in neonatal mice
Author(s) -
Nemati Afsaneh,
Beyranvand Fatemeh,
Assadollahi Vahideh,
Salahshoor Mohammad Reza,
Alasvand Masoud,
Gholami Mohammad Reza
Publication year - 2021
Publication title -
birth defects research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 17
ISSN - 2472-1727
DOI - 10.1002/bdr2.1844
Subject(s) - malondialdehyde , pregnancy , follicle , folliculogenesis , endocrinology , medicine , ovary , cerium oxide , andrology , chemistry , biology , oxidative stress , oxide , lactation , genetics , organic chemistry
Objectives Cerium is a member of the rare metals group and widely used in drug delivery, gene therapy, molecular imaging and medicine. In this study, we investigated the effect of different doses of Cerium (IV) oxide (CeO 2 ) during pregnancy on neonatal mice ovaries, as well as its effect on blood biochemical parameters. Methods Thirty pregnant NMRI mice were divided into five groups: Control and 4 groups treated with CeO 2 (10, 25, 80, 250 mg/kg.bw i.p) at the GD7 and GD14. The ovarian histological of neonatal (2 and 6 day‐olds), as well as blood serum of neonates at 15‐dpp were analyzed. Results Count of ovarian primordial follicles in neonates at 2 dpp showed a significant decrease in the groups treated with 80 and 250 mg/kg.bw doses of CeO 2 . There was also a significant decrease in ovarian primordial and primary follicles in neonates at 6‐dpp at 250 mg/kg.bw doses of CeO 2 in the control ( P < 0.05). There was no significant difference in serum levels of malondialdehyde and total antioxidant capacity between the experimental and control groups. Conclusions Our results suggest that the effects of CeO 2 on the ovarian tissue of neonatal mice during pregnancy may be dose‐dependent.