Premium
Pregnancy in systemic lupus erythematosus
Author(s) -
Polić Aleksandra,
Običan Sarah G.
Publication year - 2020
Publication title -
birth defects research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 17
ISSN - 2472-1727
DOI - 10.1002/bdr2.1790
Subject(s) - pregnancy , medicine , disease , fetus , lupus erythematosus , systemic lupus erythematosus , obstetrics , intensive care medicine , pediatrics , immunology , genetics , antibody , biology
Objectives Systemic lupus erythematosus (SLE) is a chronic illness that often affects women of reproductive age. The objectives of this article are to review the impact of SLE on pregnancy and current management strategies, including commonly used therapies. Methods We conducted a review of available literature on the clinical course of SLE, diagnosis, management and pregnancy complications. Results SLE has a variable clinical course characterized by flares and periods of remission and can present unique challenges in the management of obstetric patients. Pregnancy in patients with SLE is associated with multiple risks, including fetal loss, preterm birth, fetal growth restriction, and hypertensive disease. With advancements in disease treatment, many women have favorable pregnancy outcomes, but appropriate preconception counseling and disease management remain important tools in reducing complications. Conclusion Given the implications SLE can have on women of reproductive age and in pregnancy, understanding the disease course and management is important in order to optimize pregnancy outcomes.