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Maternal risk factors for gastroschisis: A population‐based case–control study
Author(s) -
Raitio Arimatias,
Tauriainen Asta,
Lein Maarit K,
Syvänen Johanna,
Kemppainen Teemu,
Löyttyniemi Eliisa,
Sankilampi Ulla,
Gissler Mika,
Hyvärinen Anna,
Helenius Ilkka
Publication year - 2020
Publication title -
birth defects research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 17
ISSN - 2472-1727
DOI - 10.1002/bdr2.1703
Subject(s) - gastroschisis , medicine , risk factor , gestational age , obesity , obstetrics , abdominal wall defect , logistic regression , pregnancy , population , case control study , abdominal wall , pediatrics , fetus , surgery , environmental health , biology , genetics
Background Gastroschisis is an open abdominal wall defect with low mortality but significant morbidity. The prevalence has been increasing worldwide for the past decades. Several risk factors for gastroschisis have been identified, but no clear reason for increasing prevalence has been found. In our study, we aimed to assess and identify maternal risk factors for gastroschisis. Methods In our nationwide register‐based case–control study, we identified all gastroschisis cases in the Finnish Register of Congenital Malformations from 2004 to 2014. Information on drug prescriptions and purchases was received from Drugs and Pregnancy database. Five healthy age‐matched controls from the same geographical region were randomly selected for each case. Conditional logistic regression was used to evaluate different risk factors. Results One‐hundred‐eighty‐eight cases of gastroschisis were identified and compared with 910 matched controls. Nulliparity was a significant risk factor for gastroschisis, aOR 2.00 (95% CI 1.29–3.11) whereas obesity was protective, aOR 0.35 (95% CI 0.15–0.83). Smoking appeared to increase the risk for gastroschisis, aOR 1.32 (95% CI 0.88–1.97). The mean maternal age of newborns with gastroschisis was significantly lower than average ( p <.001). Conclusion As in previous studies, nulliparity and young maternal age were significant risk factors for gastroschisis. Maternal obesity significantly reduced the risk of gastroschisis regardless of maternal age and gestational diabetes.