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Angiotensin‐converting enzyme insertion/deletion (ACE I/D) gene polymorphism in Egyptian children with congenital heart disease
Author(s) -
Saleh Nagwan Y.,
Salem Sherif S.,
AboEl fotoh Wafaa MM.,
Soliman Shaimaa E.,
AboHaded Hany M.
Publication year - 2020
Publication title -
birth defects research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 17
ISSN - 2472-1727
DOI - 10.1002/bdr2.1700
Subject(s) - genotype , angiotensin converting enzyme , allele , polymerase chain reaction , allele frequency , medicine , polymorphism (computer science) , heart disease , gene polymorphism , population , genetics , gene , endocrinology , biology , gastroenterology , blood pressure , environmental health
Background Congenital heart diseases (CHDs) are the leading cause of infant deaths worldwide. The relationship between angiotensin‐converting enzyme (ACE) gene polymorphism and CHDs is not clear. The aim of this work is to assess the presence of an association between ACE I/D polymorphism and CHD in Egyptian population. Subjects and methods Seventy CHD cases and 70 controls were incorporated in this study. DNA was isolated from their peripheral blood, and then ACE I/D gene polymorphism was tested by polymerase chain reaction (PCR). Results There was no significant difference among the frequencies of the DD, II, and DI genotypes in patients and controls (26 [37.1%], 37 [53.3%], and 4 [5.7%], 5 [6.7%]), 40 (57.2%), 28 (40%), respectively ( p value = 1 and OR [95% CI] = 1.1). There was no significant difference between D allele (DD + DI) and II genotype distribution among patients and controls ( p value = 1 and OR [95% CI] = 1.2 [0.3–2.9]). Moreover, there was no difference between I allele (II + DI) and DD frequency ( p value = 0.2 and OR [95% CI] = 0.6 [0.3–1.2]). Conclusions ACE I/D gene polymorphism might not be a risk factor of CHD in Egyptian children. Additional widespread studies are needed to affirm these data.