Association Study of Transforming Growth Factor Alpha Taq I Polymorphism and the Risk of Cleft Lip and/or Palate in an Iranian Population

Background The aim of this study is to evaluate the association of TGFA Taq I polymorphism with nonsyndromic cleft lip and/or palate (NSCLP) in an Iranian population. Methods In this case–control study, 113 children with NSCLP and 209 controls were included. Genotyping of the Taq I polymorphism was performed by polymerase chain reaction and restriction fragment length polymorphism methods. A p ‐value of <0.05 was considered statistically significant. Results For the TGFA Taq I polymorphism, the distributions of genotypes in the NSCLP ( p = 0.810) and control group ( p = 0.422) were in Hardy‐Weinberg equilibrium. There was no statistically significant difference in the genotype distribution ( p = 0.059) and allele frequency ( p = 0.065) of the TGFA Taq I polymorphism in the NSCLP and control groups. Conclusion TGFA Taq I polymorphism was not associated with the risk of NSCLP in Iranian children. Birth Defects Research 109:1386–1389, 2017.© 2017 Wiley Periodicals, Inc.