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Pre‐ and Postnatal Development of the Eye: A Species Comparison
Author(s) -
Van Cruchten Steven,
Vrolyk Vanessa,
Perron Lepage MarieFrance,
Baudon Marie,
Voute Hélène,
Schoofs Sabine,
Haruna Julius,
BenoitBiancamano MarieOdile,
Ruot Benoît,
Allegaert Karel
Publication year - 2017
Publication title -
birth defects research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 17
ISSN - 2472-1727
DOI - 10.1002/bdr2.1100
Subject(s) - nictitating membrane , eye development , biology , human eye , zoology , phenotype , genetics , computer science , statistics , classical conditioning , mathematics , artificial intelligence , conditioning , gene
In this review paper, literature data on pre‐ and postnatal eye development are compared between humans and nonclinical species that are commonly used for human safety assessment, namely, mouse, rat, rabbit, dog, minipig, and nonhuman primates. Some new data on rat and minipig ocular development are also included. This compiled information can be helpful for species selection in juvenile toxicity studies or assist in the interpretation of (non)clinical data during pediatric drug development. Despite some differences in developmental windows and anatomical peculiarities, such as the lack of a fovea centralis in nonprimate species or the presence of a nictitating membrane in some nonclinical species, the functioning and development of the eye is strikingly similar between humans and other mammals. As such, all commonly used nonclinical species appear to be relatively good models for human eye development, although some practical constraints such as size may be a limiting factor. Birth Defects Research 109:1540–1567, 2017. © 2017 Wiley Periodicals, Inc.