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Infantile Hemangiomas: An Updated Review on Risk Factors, Pathogenesis, and Treatment
Author(s) -
Smith Chelsey J. Forbess,
Friedlander Sheila Fallon,
Guma Monica,
Kavanaugh Arthur,
Chambers Christina D.
Publication year - 2017
Publication title -
birth defects research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 17
ISSN - 2472-1727
DOI - 10.1002/bdr2.1023
Subject(s) - pathogenesis , disfigurement , presentation (obstetrics) , medicine , pediatrics , intensive care medicine , pathology , surgery
Infantile hemangiomas (IHs) are the most common vascular tumors in infants, appearing in early infancy and ultimately regressing with time. Clinical presentation may vary, with a minority of lesions causing impairment of vital function (e.g., respiratory or visual obstruction), permanent scarring, and/or disfigurement. The pathogenesis of IH is complex and poorly understood. Risk factors implicated in their development include preterm birth and placental anomalies. IH presents a myriad of clinical challenges, including correct diagnosis and whether or not to pursue treatment. This article is a review of the current literature regarding pathogenesis, clinical presentation, treatment, and prognosis of IH. Birth Defects Research 109:809–815, 2017. © 2017 Wiley Periodicals, Inc.