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In vitro – in vivo correlation of modified release dosage form of lamotrigine
Author(s) -
Shah Hiten J.,
Subbaiah Gunta,
Patel Dasharath M.,
Patel Chhagan N.
Publication year - 2009
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.688
Subject(s) - ivivc , lamotrigine , in vivo , pharmacokinetics , bioavailability , chemistry , dosage form , pharmacology , dissolution testing , chromatography , dissolution , in vitro , medicine , biochemistry , organic chemistry , biopharmaceutics classification system , epilepsy , microbiology and biotechnology , psychiatry , biology
The plasma concentration profile of lamotrigine was predicted from the dissolution test data of the modified release 100 mg lamotrigine tablet by applying the in vitro–in vivo correlation (IVIVC). Three different release formulations (L‐1, L‐2 and L‐3) and its profiles of in vitro data were generated in different dissolution media. Pharmacokinetics evaluation of these formulations was carried out in 12 healthy volunteers. In vitro–in vivo correlation was established from the generated dissolution and bioavailability data. A good correlation between the percentages dissolved vs absorbed ( r 2 >0.989) was obtained using level A correlation. Evaluation of the internal predictability of level A correlation was calculated in terms of percent prediction error, which was found to be below 15%. Copyright © 2009 John Wiley & Sons, Ltd.

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