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Nrf2 plays an important role in coordinated regulation of Phase II drug metabolism enzymes and Phase III drug transporters
Author(s) -
Shen Guoxiang,
Kong AhNg
Publication year - 2009
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.680
Subject(s) - drug metabolism , enzyme , xenobiotic , transporter , transcription factor , drug , detoxification (alternative medicine) , metabolism , biology , pharmacology , chemistry , biochemistry , gene , medicine , alternative medicine , pathology
The nuclear transcription factor E2‐related factor 2 (Nrf2) has been shown to play pivotal roles in preventing xenobiotic‐related toxicity and carcinogen‐induced carcinogenesis. These protective roles of Nrf2 have been attributed in part to its involvement in the induction of Phase II drug conjugation/detoxification enzymes as well as antioxidant enzymes through the Nrf2‐antioxidant response element (ARE) signaling pathways. This review summarizes the current research status of the identification of Nrf2‐regulated drug metabolism enzymes (DMEs), especially Phase II DMEs, and Phase III drug transporters. In addition, the molecular mechanisms underlying the coordinated regulation of Phase II DMEs and Phase III transporters will also be discussed based on findings published in the literature. Copyright © 2009 John Wiley & Sons, Ltd.