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ABC transporters and isothiocyanates: potential for pharmacokinetic diet–drug interactions
Author(s) -
Telang Urvi,
Ji Yan,
Morris Marilyn E.
Publication year - 2009
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.668
Subject(s) - atp binding cassette transporter , cruciferous vegetables , transporter , phenethyl isothiocyanate , pharmacology , pharmacokinetics , multidrug resistance associated protein 2 , efflux , isothiocyanate , drug , chemistry , abcg2 , p glycoprotein , biochemistry , cancer , biology , medicine , multiple drug resistance , gene , antibiotics
Isothiocyanates, a class of anti‐cancer agents, are derived from cruciferous vegetables such as broccoli, cabbage and watercress, and have demonstrated chemopreventive activity in a number of cancer models and epidemiologic studies. Due to public interest in cancer prevention and alternative therapies in cancer, the consumption of herbal supplements and vegetables containing these compounds is widespread and increasing. Isothiocyanates interact with ATP‐binding cassette (ABC) efflux transporters such as P‐glycoprotein, MRP1, MRP2 and BCRP, and may influence the pharmacokinetics of substrates of these transporters. This review discusses the pharmacokinetic properties of isothiocyanates, their interactions with ABC transporters, and presents some data describing the potential for isothiocyanate‐mediated diet–drug interactions. Copyright © 2009 John Wiley & Sons, Ltd.