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Evaluation of gender in the oral pharmacokinetics of clindamycin in humans
Author(s) -
CarrascoPortugal Miriam del Carmen,
Luján Miguel,
FloresMurrieta Francisco Javier
Publication year - 2008
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.624
Subject(s) - pharmacokinetics , clindamycin , pharmacology , medicine , cyp3a4 , plasma concentration , plasma levels , oral dose , drug , body weight , oral administration , antibiotics , chemistry , metabolism , cytochrome p450 , biochemistry
Clindamycin is an antimicrobial agent metabolized by CYP3A4. Gender may influence the pharmacokinetics of drugs metabolized by this pathway, however, no information about differences in the pharmacokinetics of clindamycin in men and women is available. The purpose of this study was to evaluate gender differences in clindamycin oral pharmacokinetics. Twenty‐four subjects (11 men and 13 women) received an oral 600 mg dose of clindamycin under fasting conditions and plasma concentrations were obtained at selected times during 12 h. Increased plasma levels were observed in women, but when the dose was normalized by the body weight of individuals, these differences disappeared, indicating that gender does not play an important role in the pharmacokinetics of this drug. Copyright © 2008 John Wiley & Sons, Ltd.