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A simple pharmacokinetics subroutine for modeling double peak phenomenon
Author(s) -
Mirfazaelian Ahmad,
Mahmoudian Massoud
Publication year - 2006
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.492
Subject(s) - subroutine , pharmacokinetics , piroxicam , computer science , mathematics , algorithm , pharmacology , medicine , alternative medicine , pathology , operating system
Double peak absorption has been described with several orally administered drugs. Numerous reasons have been implicated in causing the double peak. DRUG‐KNT—a pharmacokinetic software developed previously for fitting one and two compartment kinetics using the iterative curve stripping method—was modified and a revised subroutine was incorporated to solve double‐peak models. This subroutine considers the double peak as two hypothetical doses administered with a time gap. The fitting capability of the presented model was verified using four sets of data showing double peak profiles extracted from the literature (piroxicam, ranitidine, phenazopyridine and talinolol). Visual inspection and statistical diagnostics showed that the present algorithm provided adequate curve fit disregarding the mechanism involved in the emergence of the secondary peaks. Statistical diagnostic parameters ( RSS , AIC and R 2 ) generally showed good fitness in the plasma profile prediction by this model. It was concluded that the algorithm presented herein provides adequate predicted curves in cases of the double peak phenomenon. Copyright © 2006 John Wiley & Sons, Ltd.