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On the assessment of effects of food on the pharmacokinetics of drugs in early development
Author(s) -
Li Zhihong,
Vachharajani Nimish N.,
Krishna Rajesh
Publication year - 2002
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.309
Subject(s) - pharmacokinetics , drug , pharmacology , drug development , medicine
The impact of food on the pharmacokinetics of a drug has important implications in drug development. This commentary is aimed at addressing two key challenges, developability of drugs whose pharmacokinetics are severely influenced by food, and the need for addressing the effects of fruit juice ingredients which modulate metabolic/efflux properties of a compound. Perspectives on the value in predicting food‐drug interactions during preclinical development, timing of clinical food‐drug interaction studies, and implications of food effects are presented herein. Copyright © 2002 John Wiley & Sons, Ltd.