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A study of streptomycin blood level information of patients undergoing hemodialysis
Author(s) -
Akaho Eiichi,
Maekawa Takashi,
Uchinashi Masako,
Kanamori Ryuichi
Publication year - 2002
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.293
Subject(s) - hemodialysis , pharmacokinetics , medicine , streptomycin , blood concentration , intramuscular injection , urology , chemistry , surgery , database , pharmacology , biochemistry , antibiotics , computer science
Pharmacokinetic feature of streptomycin (SM) was investigated before and during hemodialysis (HD) in four patients with renal failure undergoing HD. SM concentrations were assayed by using TDX SM KIT (DAINABOT). Patients received 10 mg/kg of SM by intramuscular injection before HD. Pharmacokinetic parameters of SM intramuscular injection before HD were k a =2.38±0.53 h −1 ; k e =0.0130±0.0025 h −1 ; V d =0.313±0.026l/kg and t 1/2 =55.6±10.4 h. The maximum concentration ( C max ) of SM was observed at about 2 h after the SM administration and the mean serum concentration of SM was 30.4 µg/ml; even 4 h after the SM injection, the concentration still remained in a range over 30 µg/ml. The data suggest that a possible toxicity might have appeared in the patients. During the hemodialysis an average t 1/2 value was 3.32 h. This value is close to the value of a healthy person. The k e value of patient A during the hemodialysis became 24 times as large as that observed before the hemodialysis. On the average it was 17 times as large as that observed before the hemodialysis. Thus, it was found that the values of pharmacokinetics parameters such as k e and t 1/2 during the hemodialysis were similar to those of a healthy person, although there are some variations. Copyright © 2002 John Wiley & Sons, Ltd.