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Effect of smoking on single dose pharmacokinetics of phenobarbital
Author(s) -
Mirfazaelian A.,
Jahanzad F.,
Tabatabaeifar M.,
Farsam H.,
Mahmoudian M.
Publication year - 2001
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.284
Subject(s) - pharmacokinetics , phenobarbital , pharmacology , drug , medicine , pharmacokinetic interaction , plasma levels , chemistry , drug interaction
In order to determine interaction of smoking with single dose pharmacokinetics of phenobarbital, a 60 mg tablet of the drug was given to 12 healthy male subjects in two groups (6 smokers and 6 non‐smokers) in a double blind study. An HPLC method using UV detection was developed to assess phenobarbital in plasma of the subjects. Pharmacokinetic parameters were calculated and compared in the two groups. Pharmacokinetic parameters of the two groups were not significantly different in the two groups ( p <0.05). The results show no considerable effect of cigarette smoking on phenobarbital pharmacokinetics, which is in agreement with enzyme studies performed previously. Copyright © 2001 John Wiley & Sons, Ltd.