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The effect of caffeine on the pharmacokinetics of acetaminophen in man
Author(s) -
Iqbal Nadeem,
Ahmad Bashir,
Janbaz Khalid Hussain,
Gilani AnwarUl Hassan,
Niazi Sarfaraz Khan
Publication year - 1995
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510160606
Subject(s) - caffeine , pharmacokinetics , acetaminophen , pharmacology , medicine , chemistry
The influence of caffeine (60 mg) was studied on the pharmacokinetic characteristics of acetaminophen (500 mg single dose) in ten healthy male human volunteers in a complete cross‐over design. A high‐performance liquid chromatography (HPLC) method was used to analyse serum drug concentrations. Caffeine caused a highly significant ( p < 0.01) increase in AUC and AUMC, a significant ( p < 0.05) increase in C max , and a significant ( p < 0.05) decrease in clearance (Cl/ F ) of acetaminophen. We conclude that caffeine taken in doses commonly available commercially or in a cup of coffee can significantly potentiate the therapeutic potential of acetaminophen in man.