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Pharmacokinetics of amoxicillin coadministered with a saline‐polyethylene glycol solution in healthy volunteers
Author(s) -
Padoin C.,
Tod M.,
Brion N.,
Louchahi K.,
Le Gros V.,
Petitjean O.
Publication year - 1995
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510160302
Subject(s) - pharmacokinetics , crossover study , amoxicillin , pharmacology , placebo , absorption (acoustics) , area under the curve , polyethylene glycol , antibacterial agent , medicine , saline , chemistry , antibiotics , anesthesia , materials science , biochemistry , alternative medicine , pathology , composite material
The pharmacokinetics of orally administered amoxicillin were investigated in 12 healthy volunteers in a crossover design. They received either a placebo or a saline—polyethylene glycol solution (SPG) for 4 d, the last dose being given simultaneously with 1 g amoxicillin; blood samples were drawn for the next 12 h. Amoxicillin kinetics were similar in the two treatments but small differences in some pharmacokinetic parameters reached significance. The mean±SD area under the curve was lower with SPG (43.8±6.8 against 47.8±8.2 mg h L −1 , p <0.05) but the treatments were equivalent according to Westlake's test (95% confidence interval = 14.95%). Analysis of SPG against placebo amoxicillin absorption kinetics after fitting the data to a Weibull model revealed a longer duration of the absorption, a slower rate of absorption, and a different shape of the curve. No clinical consequences are expected from these minor variations but possible mechanisms could be relevant to other drugs.