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The effect of food on the relative bioavailability of fadrozole hydrochloride
Author(s) -
Choi R. Leslie,
Sun Jim X.,
Kochak Gregory M.
Publication year - 1993
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510140904
Subject(s) - bioavailability , cmax , crossover study , pharmacokinetics , pharmacology , ingestion , gastric emptying , biology , absorption (acoustics) , meal , oral administration , medicine , endocrinology , placebo , stomach , alternative medicine , pathology , physics , acoustics
The effect of food on the pharmacokinetic disposition of fadrozole hydrochloride was evaluated in nine healthy male and female volunteers. Single 12 mg doses of fadrozole were orally administered to subjects immediately following a standardized meal or after fasting for 12 h, in a randomized crossover design. No statistically significant treatment differences were detected for the pharmacokinetic parameters AUC and half‐life. C max was significantly reduced by 15% for the fed treatment relative to the fasted treatment, and t max was delayed by 39%. These findings indicate that the concomitant ingestion of food with fadrozole delays the gastric emptying and/or absorption of fadrozole, but has no effect on the extent of absorption.