Pharmacokinetics of fluvoxamine maleate after increasing single oral doses in healthy subjects | Zendy

De Vries M. H. | Zendy; Van Harten J. | Zendy; Van Bemmel P. | Zendy; Raghoebar M. | Zendy

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Pharmacokinetics of fluvoxamine maleate after increasing single oral doses in healthy subjects

Author(s) -

De Vries M. H.,

Van Harten J.,

Van Bemmel P.,

Raghoebar M.

Publication year - 1993

Publication title -

biopharmaceutics and drug disposition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.419

H-Index - 58

eISSN - 1099-081X

pISSN - 0142-2782

DOI - 10.1002/bdd.2510140403

Subject(s) - pharmacokinetics , fluvoxamine , pharmacology , chemistry , oral administration , medicine , fluoxetine , receptor , serotonin

The pharmacokinetics of fluvoxamine after single oral administration of 25, 50, and 100 mg fluvoxamine maleate was studied in a three‐way cross‐over study in 12 healthy male subjects. Fluvoxamine was administered orally in a solution. For doseproportionality, AUC, and C max ‐dose relationships were evaluated by linear regression. Plasma concentrations increased in a linear dose‐dependent manner in the dose range between 25 and 100 mg; t 1/2 and T max showed no significant differences among treatments. Fluvoxamine was well tolerated.

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