Premium
Pharmacokinetics of fluvoxamine maleate after increasing single oral doses in healthy subjects
Author(s) -
De Vries M. H.,
Van Harten J.,
Van Bemmel P.,
Raghoebar M.
Publication year - 1993
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510140403
Subject(s) - pharmacokinetics , fluvoxamine , pharmacology , chemistry , oral administration , medicine , fluoxetine , receptor , serotonin
The pharmacokinetics of fluvoxamine after single oral administration of 25, 50, and 100 mg fluvoxamine maleate was studied in a three‐way cross‐over study in 12 healthy male subjects. Fluvoxamine was administered orally in a solution. For doseproportionality, AUC, and C max ‐dose relationships were evaluated by linear regression. Plasma concentrations increased in a linear dose‐dependent manner in the dose range between 25 and 100 mg; t 1/2 and T max showed no significant differences among treatments. Fluvoxamine was well tolerated.