Effect of pirenzepine on the  N ‐demethylation of D(−)ephedrine and ethylmorphine by rabbit liver microsomes | Zendy

ElObeid H. A. | Zendy; AlRashood K. A. | Zendy; AlKhamees H. A. | Zendy; AlKhamis K. I. | Zendy; Mian M. S. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Effect of pirenzepine on the N ‐demethylation of D(−)ephedrine and ethylmorphine by rabbit liver microsomes

Author(s) -

ElObeid H. A.,

AlRashood K. A.,

AlKhamees H. A.,

AlKhamis K. I.,

Mian M. S.

Publication year - 1993

Publication title -

biopharmaceutics and drug disposition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.419

H-Index - 58

eISSN - 1099-081X

pISSN - 0142-2782

DOI - 10.1002/bdd.2510140310

Subject(s) - ephedrine , ethylmorphine , microsome , pirenzepine , chemistry , demethylation , pharmacology , rabbit (cipher) , endocrinology , medicine , biochemistry , in vitro , mathematics , muscarinic acetylcholine receptor , receptor , gene expression , dna methylation , gene , statistics

The possible interaction of pirenzepine with the mixed‐function oxidases obtained from phenobarbital‐pretreated rabbit microsomes was examined in vitro . Under experimental conditions that did not lead to its own N ‐demethylation, the drug inhibited the microsomal oxidase systems responsible for the N ‐demethylation of D(‐)ephedrine and ethylmorphine. Kinetic studies showed that pirenzepine inhibited the metabolism of both drugs in a competitive manner. The results indicated that the observed pirenzepine stability to the hepatic N ‐demethylating system is not a result of low affinity of the drug to the system.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research