Premium
Disposition kinetics of 7,12‐dimethylbenz(a)anthracene in rats
Author(s) -
Niazi Sarfaraz K.,
Hussain Musarrat
Publication year - 1992
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510130805
Subject(s) - dmba , disposition , carcinogen , pharmacokinetics , 7,12 dimethylbenz[a]anthracene , pharmacology , anthracene , chemistry , carcinogenesis , drug , medicine , biochemistry , psychology , social psychology , organic chemistry , gene
One of the most potent carcinogens is 7,12‐dimethylbenz(a)anthracene (7,12‐DMBA), which is used routinely to conduct studies to evaluate carcinogen inhibitors. Its pharmacokinetics have not been reported in the literature. In view of its significant effects on drug metabolizing enzymes and clearance mechanisms, it is important to know its disposition characteristics. In this study, we monitored the disposition characteristics of 7,12‐DMBA in rats as a function of dose range commonly used in carcinogenesis studies. A mean residence time of 40–55 min was observed; the total body clearance ranged from 8–13 1 kg −1 . No effect of dose was observed on the pharmacokinetic parameters. This suggests that the dose‐dependent effects of 7,12‐DMBA carcinogenesis are related to its transient disposition characteristics.