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‘ In vitro ’ action of histamine and cimetidine on amylase secretion in the rat pancreas
Author(s) -
Murillo Luis Jiménez,
TorreCisneros Julián,
BlancoMolina Angeles,
LópezMiranda José,
de la Puebla Rafael Angel Fernández,
PérezJiménez Francisco
Publication year - 1992
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510130508
Subject(s) - cimetidine , amylase , histamine , bethanechol , secretion , medicine , endocrinology , histamine h2 receptor , pancreas , receptor , chemistry , biology , enzyme , antagonist , biochemistry , muscarinic acetylcholine receptor
We report here the effect of histamine on amylase secretion in isolated lobules from the rat pancreas. Different concentrations of histamine increased amylase secretion, while the stimulatory effect was reduced by cimetidine although not by chlorpheniramine. These findings suggest that pancreatic lobules have H 2 receptors. On the other hand, bethanechol induced a stimulatory effect on pancreatic lobules that was inhibited by cimetidine. Vibrio cholerae toxin stimulated amylase secretion, but this effect was not reduced by cimetidine. Cimetidine may thus block the stimulated amylase secretion interfering with the Ca 2+ messenger system.