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A general method for calculating the mean transit times and distribution rate parameters of catenary metabolites
Author(s) -
Cheng Haiyung
Publication year - 1992
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510130304
Subject(s) - catenary , metabolite , distribution (mathematics) , pharmacokinetics , chemistry , chromatography , mathematics , pharmacology , statistics , medicine , biochemistry , mathematical analysis , geometry
A general method for calculating the mean transit times and distribution rate parameters is described. The calculations require the AUC, AUMC, and derivatives of the plasma concentration profiles of the metabolites and its precursor. The method is applicable to catenary metabolites with any precursor order and does not require separate administration of the metabolite. The approach is applied to published data for the primary and secondary metabolites of ketamine.