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Effect of dehydration on the disposition kinetics of erythromycin in rabbits
Author(s) -
Ahmad M.,
Niazi S. K.,
Ahmad T.,
Muzaffar N. A.,
Nawaz M.
Publication year - 1992
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510130202
Subject(s) - erythromycin , dehydration , disposition , pharmacokinetics , pharmacology , population , chemistry , toxicity , kinetics , antibiotics , medicine , biochemistry , psychology , social psychology , physics , environmental health , organic chemistry , quantum mechanics
The effect of water deprivation on the physiologic, biochemical, and disposition parameters of erythromycin was investigated in rabbits. The packed cell volume, plasma glucose, and total lipid concentration increased significantly in dehydration. The pharmacokinetic parameters of erythromycin after intravenous administration also changed, suggesting a need for monitoring toxicity of erythromycin in the water‐deprived population.