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The effect of age on the pharmacokinetics of pentisomide
Author(s) -
Holt D. W.,
Walker S.,
Johnston A.,
Jones R. W.,
Howse N. L.,
Darragh A.,
Caffrey E.
Publication year - 1991
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510120808
Subject(s) - pharmacokinetics , medicine , renal function , dosing , plasma clearance , impaired renal function , oral administration , creatinine , drug , pharmacology
The effects of age on the pharmacokinetics of pentisomide (CM7857), an orally effective antiarrhythmic agent, were studied in two groups of volunteers. Sixteen young volunteers (mean age 26·4 years) and 10 elderly volunteers (mean age 67·8 years) received a single 200 mg oral dose of pentisomide. Mean AUC was larger and terminal elimination half‐life longer in the elderly subjects, due to a decrease in total plasma clearance of pentisomide in the elderly. This decrease was due to a reduction in renal clearance of the drug which was paralleled by a significantly lower creatinine clearance in the elderly subjects. Dosage reduction, or a reduced frequency of dosing of pentisomide would be necessary in the elderly or those with impaired renal function.