Premium
Comparison of in vitro and in vivo release characteristics of acetaminophen from gradient matrix systems
Author(s) -
Van Bommel Elvira M. G.,
Raghoebar Maikel,
Tukker Josef J.
Publication year - 1991
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510120506
Subject(s) - in vivo , in vitro , acetaminophen , matrix (chemical analysis) , immediate release , chemistry , liberation , concentration gradient , pharmacology , chromatography , biochemistry , biology , microbiology and biotechnology
An effort was made to correlate the in vivo and in vitro release data of acetaminophen from two formulations of a recently developed controlled‐release system, the Gradient Matrix System (GMS‐1 and GMS‐2). The in vivo release curves, obtained by deconvolution of the plasma concentration time plots, showed a small inter‐subject variability. GMS‐1 with fastest in vitro release also showed fastest in vivo release. A good relationship was only found after time‐scaling of the release data.