Comparison of  in vitro  and  in vivo  release characteristics of acetaminophen from gradient matrix systems | Zendy

Van Bommel Elvira M. G. | Zendy; Raghoebar Maikel | Zendy; Tukker Josef J. | Zendy

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Comparison of in vitro and in vivo release characteristics of acetaminophen from gradient matrix systems

Author(s) -

Van Bommel Elvira M. G.,

Raghoebar Maikel,

Tukker Josef J.

Publication year - 1991

Publication title -

biopharmaceutics and drug disposition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.419

H-Index - 58

eISSN - 1099-081X

pISSN - 0142-2782

DOI - 10.1002/bdd.2510120506

Subject(s) - in vivo , in vitro , acetaminophen , matrix (chemical analysis) , immediate release , chemistry , liberation , concentration gradient , pharmacology , chromatography , biochemistry , biology , microbiology and biotechnology

An effort was made to correlate the in vivo and in vitro release data of acetaminophen from two formulations of a recently developed controlled‐release system, the Gradient Matrix System (GMS‐1 and GMS‐2). The in vivo release curves, obtained by deconvolution of the plasma concentration time plots, showed a small inter‐subject variability. GMS‐1 with fastest in vitro release also showed fastest in vivo release. A good relationship was only found after time‐scaling of the release data.

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