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Effects of ethanol and Δ 9 ‐tetrahydrocannabinol on phencyclidine disposition in dogs
Author(s) -
Godley Paul J.,
Moore Emory S.,
Woodworth James R.,
Fineg Jerry
Publication year - 1991
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510120303
Subject(s) - phencyclidine , pharmacokinetics , chemistry , pharmacology , cannabinol , cannabidiol , δ9 tetrahydrocannabinol , tetrahydrocannabinol , hallucinogen , crossover study , delta 9 tetrahydrocannabinol , ethanol , cannabinoid , cannabis , medicine , biochemistry , placebo , nmda receptor , receptor , alternative medicine , pathology , psychiatry
A three‐way crossover study was performed to determine the influence of Δ 9 ‐tetrahydro‐cannabinol (THC) and ethanol (EtOH) separately upon phencyclidine (PCP) disposition in dogs. Seven dogs were given three single dose treatments: 1·5mg PCP kg −1 i.v., 1·5 mg PCP kg −1 i.v. with 0·4mgkg −1 THC i.v., and 1·5 mg PCP kg −1 i.v. with 1·25g EtOH kg −1 i.v. PCP was measured in plasma samples collected for 24h after administration of each treatment, with several pharmacokinetic parameters calculated from the plasma concentration vs time data. The PCP serum Cl s values were significantly lower when administered with THC than when administered alone, with no significant change in V β or t 1/2 . EtOH did not induce significant changes in any PCP pharmacokinetic parameter, although mean Cl s and V β were increased. These results confirm the observed THC inhibition of PCP metabolism, and suggest that the enhanced pharmacologic action of PCP by THC may result from higher serum PCP concentrations. These results further suggest that enhanced PCP actions by acute EtOH administration may result from increased PCP distribution to the CNS.