Premium
Drug redistribution and mean transit time concepts for nonlinear pharmacokinetic systems
Author(s) -
Cheng Haiyung,
Jusko William J.
Publication year - 1991
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510120108
Subject(s) - pharmacokinetics , redistribution (election) , drug , nonlinear system , medicine , pharmacology , computer science , physics , political science , quantum mechanics , politics , law
Equations for the mean number of cycles through the peripheral system ( R ) and the mean transit time through the central compartment ( MTT c ) are derived for intravenous drugs with linear distribution and linear or nonlinear central elimination. This R is a function of distribution clearance (CL D ), dose, and area under the plasma concentration–time curve (AUC). The MTT c is a function of the central volume of distribution, CL D , dose, and AUC. The application of the proposed calculations of R and MTT c was illustrated by computer simulations.