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A high‐performance liquid chromatographic method for the determination of stobadin pharmacokinetics in serum
Author(s) -
Šoltés Ladislav,
Kállay Zoltán,
Bezek Štefan,
Fedelesǒvá Viera
Publication year - 1991
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510120104
Subject(s) - pharmacokinetics , bioavailability , chromatography , chemistry , high performance liquid chromatography , serum concentration , pharmacology , medicine
A high‐performance liquid chromatographic method was developed to determine stobadin pharmacokinetics in dog and man. The relative bioavailability of stobadin dipalmitate compared with dihydrochloride was 46·4 per cent in dog. In man peak serum concentrations ranged from 12 to 289ng ml −1 after a single oral dose of stobadin dipalmitate (0·79 to 2·5mg kg −1 ).