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Pharmacokinetic modelling of the plasma concentration‐time profile of the vitamin retinyl palmitate following intramuscular administration
Author(s) -
Hartmann D.,
Gysel D.,
Dubach U. C.,
Forgo I.
Publication year - 1990
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510110805
Subject(s) - bioavailability , pharmacokinetics , absorption (acoustics) , chemistry , plasma concentration , vitamin , retinyl palmitate , half life , plasma levels , pharmacology , medicine , chromatography , endocrinology , retinol , physics , acoustics
Seven healthy male volunteers (21–24 y) received by the ventro‐gluteal route a single dose of 100 000 I.U. of the vitamin retinyl palmitate (RP) in a water‐miscible preparation (W) and 5 weeks later the same dose in an oily solution (S). After administration of W median (range) peak plasma concentrations of 5.6(4.4–8.7). 10 3 μg 1‐ −1 were reached after 12 h and high levels persisted for another 50 h. At 144 h levels were still, by a factor 3, higher than baseline. Plasma levels of RP after S remained close to baseline (20–50 μg.1 −1 ) suggesting negligibly low bioavailability. The plasma level profile of RP after W could well be described by use of a one‐compartment model with Weibull‐type absorption and Michaelis‐Menten elimination. The median (range) absolute bioavailability (estimates of lower limits) was 42 (32–52) per cent.