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Elevation of carbamazepine plasma levels by diltiazem in rabbits: A potentially important drug interaction
Author(s) -
AlHumayyd Mohammad Saad
Publication year - 1990
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510110506
Subject(s) - diltiazem , carbamazepine , pharmacology , pharmacokinetics , plasma concentration , drug , drug interaction , chemistry , plasma levels , medicine , epilepsy , calcium , psychiatry
The effect of diltiazem on the plasma level of carbamazepine (CBZ) was investigated in rabbits. The animals were given either CBZ alone or in combination with diltiazem and plasma samples were collected at different time intervals. The concentration of CBZ was detected using an HPLC method. Diltiazem significantly increased the area under the curve (AUC), the maximum plasma concentration ( C max ), and the elimination half‐life ( t 1/2 ) of CBZ ( p < 0·05). These results suggest that a potentially harmful drug‐ drug interaction may occur if CBZ and diltiazem are administered concurrently.