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Pharmacokinetic aspects of the sublingual administration of vincamine
Author(s) -
Aiache JM.,
Delatte MC.,
Leblanc PP.,
Kantelip JP.,
Steimer JL.
Publication year - 1990
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510110402
Subject(s) - pharmacokinetics , absorption (acoustics) , buccal administration , pharmacology , gastrointestinal tract , sublingual administration , chemistry , drug , saliva , oral administration , buccal mucosa , chromatography , medicine , materials science , biochemistry , dentistry , oral cavity , composite material
The sublingual absorption of vincamine used as tracer occurs in two successive absorption steps: true sublingual absorption and absorption in the gastrointestinal tract of the drug dissolved in the saliva and not absorbed through the buccal mucosa. This is confirmed by a pharmacokinetic study and simulation. These two successive absorptions can explain the increase in the amounts of drug absorbed.