Absorption kinetics of cyclosporine in healthy volunteers | Zendy

Gupta Suneel K. | Zendy; Benet Leslie Z. | Zendy

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Absorption kinetics of cyclosporine in healthy volunteers

Author(s) -

Gupta Suneel K.,

Benet Leslie Z.

Publication year - 1989

Publication title -

biopharmaceutics and drug disposition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.419

H-Index - 58

eISSN - 1099-081X

pISSN - 0142-2782

DOI - 10.1002/bdd.2510100608

Subject(s) - bioavailability , absorption (acoustics) , kinetics , pharmacokinetics , pharmacology , oral administration , zero order , absorption rate , chemistry , medicine , first order , chromatography , mathematics , materials science , physics , composite material , quantum mechanics

The absorption kinetics of cyclosporine were studied in eight healthy volunteers following oral and intravenous administration. Bioavailability of cyclosporine was observed to be 20±8 ± 5·5 per cent. Absorption of cyclosporine was found to be better described by first order processes rather than by a zero order process as previously reported.

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