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Absorption kinetics of cyclosporine in healthy volunteers
Author(s) -
Gupta Suneel K.,
Benet Leslie Z.
Publication year - 1989
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510100608
Subject(s) - bioavailability , absorption (acoustics) , kinetics , pharmacokinetics , pharmacology , oral administration , zero order , absorption rate , chemistry , medicine , first order , chromatography , mathematics , materials science , physics , composite material , quantum mechanics
The absorption kinetics of cyclosporine were studied in eight healthy volunteers following oral and intravenous administration. Bioavailability of cyclosporine was observed to be 20±8 ± 5·5 per cent. Absorption of cyclosporine was found to be better described by first order processes rather than by a zero order process as previously reported.