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Interspecies pharmacokinetic scaling of metazosin, a novel alpha‐adrenergic antagonist
Author(s) -
Lapka Roman,
Rejholec Václav,
Sechser Tomás,
Peterková Marcela,
Šmíd Milan
Publication year - 1989
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510100607
Subject(s) - pharmacokinetics , volume of distribution , distribution (mathematics) , pharmacology , allometry , chemistry , medicine , mathematics , biology , mathematical analysis , ecology
Based on pharmacokinetic data from mice, rats, and rabbits the prediction of pharmacokinetics of intravenous metazosin in man has been performed. The correlations were based upon allometric scaling of plasma clearance and the volume of distribution at steady‐state. A one‐compartment body model approximating clinical pharmacokinetics fits well the elimination phase of subsequently measured metazosin concentrations in volunteers. Fitting human pharmacokinetic data to allometric equations enabled us to superimpose pharmacokinetic curves from different species.