Premium
The absorption of sustained‐release methylphenidate formulations compared to an immediate‐release formulation
Author(s) -
Patrick Kennerly S.,
Straughn Arthur B.,
Jarvi Eric J.,
Breese George R.,
Meyer Marvin C.
Publication year - 1989
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510100206
Subject(s) - methylphenidate , pharmacology , absorption (acoustics) , immediate release , pharmacokinetics , medicine , chemistry , anesthesia , chromatography , psychiatry , materials science , attention deficit hyperactivity disorder , composite material
A crossover study in 18 subjects evaluated the plasma concentration–time profile of two different 20 mg sustained‐release (SR) methylphenidate (MPH) tablets administered before breakfast, compared to a 10 mg immediate‐release (IR) tablet administered before breakfast and again 5 h later, before lunch. Plasma MPH concentrations were determined using a sensitive and precise gas chromatography–mass spectrometry method, incorporating a deuterated internal standard. The mean peak MPH concentration was 6.4 ng ml −1 for the IR product versus 4·6 ng ml −1 and 4·8 ng ml −1 for the two SR formulations. Peak concentrations occurred at 3·3 h after dosing with the SR products, compared to 1·5 h after the first dose of the IR product. The extent of absorption for the three products, as determined from areas under the plasma concentration‐time curves, were within 5 per cent of each other. There was no significant difference in rate or extent of absorption between the two SR formulations.