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Effect of domperidone on cimetidine and ranitidine absorption in rabbits
Author(s) -
AlKhamis Khalil I.,
Kaka Juzar S.,
Matar Kamal M.
Publication year - 1987
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510080403
Subject(s) - cimetidine , domperidone , ranitidine , pharmacokinetics , absorption (acoustics) , oral administration , histamine h2 receptor , chemistry , plasma concentration , medicine , pharmacology , receptor , antagonist , physics , acoustics , dopamine
Abstract Cimetidine and ranitidine absorption were studied after oral administration to rabbits, alone or in combination with oral and intravenous domperidone. Blood samples were collected before and 0.25, 0.5, 0.75, 1.0, 1.5, 2.0, 3.0, 4.5, and 6.0h after cimetidine and ranitidine administration. Assays of cimetidine and ranitidine in plasma samples were carried out using HPLC method. Domperidone overall significantly reduced the area under the plasma concentration‐time curve (AUC) by approximately 30 per cent for both drugs. However, domperidone had little effect on the maximum plasma concentration ( C max ), the time taken to reach the maximum plasma concentration ( T max ), and the elimination half‐life ( t 1/2 ) of cimetidine and ranitidine. The results suggest that domperidone affects the extent but not the rate of cimetidine and ranitidine absorption by enhancing gastric emptying.