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Pharmacokinetics of dexamethasone and its phosphate ester
Author(s) -
Rohdewald Peter,
Möllmann Helmut,
Barth Jürgen,
Rehder Jörg,
Derendorf Hartmut
Publication year - 1987
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510080302
Subject(s) - dexamethasone , pharmacokinetics , prodrug , chemistry , pharmacology , phosphate , dosing , plasma concentration , corticosteroid , plasma levels , medicine , endocrinology , biochemistry
Dexamethasone in form of its phosphate was given intravenously in two different doses (1.5mg kg −1 and 15 mg). Plasma levels of the ester and dexamethasone were measured and pharmacokinetic parameters were calculated. The results indicate no dose‐dependency of the pharmacokinetic parameters in the investigated range for dexamethasone. Conversion from the prodrug to the active form was rapid; maximum dexamethasone plasma concentrations were reached after 10 min. The results were verified by dexamethasone level monitoring in patients after chronic dosing. Predicted and achieved steady state levels agreed well.