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Definition of mean residence times in pharmacokinetics
Author(s) -
Cutler David J.
Publication year - 1987
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510080110
Subject(s) - residence , residence time (fluid dynamics) , statistics , pharmacokinetics , mathematics , computer science , econometrics , medicine , pharmacology , sociology , engineering , demography , geotechnical engineering
A new definition of the mean residence time is proposed which includes the commonly used definition as a special case. The advantage of the new definition is that it applies for both linear and non‐linear systems. Some practical advantages which follow from the new definition are discussed. Procedures for using urinary excretion data in mean residence time estimation are discussed.