Premium
Lack of effect of multiple doses of cimetidine on estimated hepatic blood flow
Author(s) -
Grasela Dennis M.,
Rocci Mario L.,
Rotmensch Heschi H.,
Vlasses Peter H.
Publication year - 1987
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510080108
Subject(s) - cimetidine , supine position , placebo , indocyanine green , medicine , blood flow , analysis of variance , pharmacokinetics , anesthesia , surgery , alternative medicine , pathology
Conflicting data exists regarding the effect of the H 2 ‐receptor blocking agent cimetidine on hepatic blood flow (HBF). The variance in the results of these studies may be due in part to differences in the duration of cimetidine administration, the posture of the volunteers during their course of study, and the method used to estimate HBF. To assess the effects of chronic cimetidine (300 mg q.i.d. × 4 days) on estimated HBF while controlling posture (supine and standing), a double‐blind, placebo‐controlled, repeated measures study was performed in 9 healthy males. Indocyanine green (ICG) plasma clearance after an i.v. dose of 0.5 mg kg −1 was used to calculate HBF. ICG plasma concentrations were measured by HPLC. Compared to placebo treatment, cimetidine had no effect on mean (SD) estimated HBF (ml min −1 m −2 ) in either the supine (497 (64) vs 494 (80)) or the standing (443 (117) vs 404 (89)) posture. These data had a power > 0.8 to detect a treatment effect of 20 per cent. Standing produced a significant decrease in estimated HBF (496 (70) vs 424 (102); p < 0.01). In contrast to previous reports, chronic cimetidine treatment had no apparent effect on hepatic blood flow.