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Correlation between inhibitory effect on platelet aggregation and disposition of sulfinpyrazone and its metabolites in rabbits. Part II: Multiple dose study
Author(s) -
Kuo BeSheng,
Ritschel Wolfgang A.
Publication year - 1987
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510080103
Subject(s) - sulfinpyrazone , pharmacology , chemistry , crossover study , metabolite , pharmacokinetics , dosing , disposition , biochemistry , medicine , aspirin , alternative medicine , pathology , placebo , psychology , social psychology
In a crossover study rabbits were given perorally sulfinpyrazone (SO) and the sulfide metabolite (S) every 24h for 5 days on separate occasions and inhibition of aggregation was measured. The results showed: (1) the dosage regimen is effective if the minimum effective concentration of S is defined to be between 0.5–1.0μg ml −1 and (2) the repeated dosing did not cause changes in disposition kinetics except that the terminal half‐life of S was reduced after dosing with S. No significant accumulations in trough concentration and inhibition of aggregation were observed. The results obtained in this study could provide some useful information for design of dosage regimen and blood level monitoring for humans.