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Bioavailability of cyanamide in fasted and unfasted rats
Author(s) -
Obach R.,
Valenti C.,
Valles J.,
Valles J. M.,
Domenech J.
Publication year - 1986
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510070308
Subject(s) - cyanamide , bioavailability , pharmacokinetics , absorption (acoustics) , chemistry , pharmacology , oral administration , plasma concentration , medicine , biochemistry , physics , acoustics
The pharmacokinetics of cyanamide after 35 mg kg −1 intravenous and oral administration to fasted and unfasted rats have been investigated. The plasma level are fitted well by a two‐compartment open model. The half‐life ( t 1/2 β) of cyanamide in the rat was 1 hour and the plasma clearance (C1 p ) was 0.02 (1 kg −1 ) min −1 . Food does not appear to modify the absolute bioavailability of cyanamide ( F = 93.3 per cent fasted, F = 85.5 per cent unfasted), although it does retard drug absorption.