Bioavailability of cyanamide in fasted and unfasted rats | Zendy

Obach R. | Zendy; Valenti C. | Zendy; Valles J. | Zendy; Valles J. M. | Zendy; Domenech J. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Bioavailability of cyanamide in fasted and unfasted rats

Author(s) -

Obach R.,

Valenti C.,

Valles J.,

Valles J. M.,

Domenech J.

Publication year - 1986

Publication title -

biopharmaceutics and drug disposition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.419

H-Index - 58

eISSN - 1099-081X

pISSN - 0142-2782

DOI - 10.1002/bdd.2510070308

Subject(s) - cyanamide , bioavailability , pharmacokinetics , absorption (acoustics) , chemistry , pharmacology , oral administration , plasma concentration , medicine , biochemistry , physics , acoustics

The pharmacokinetics of cyanamide after 35 mg kg −1 intravenous and oral administration to fasted and unfasted rats have been investigated. The plasma level are fitted well by a two‐compartment open model. The half‐life ( t 1/2 β) of cyanamide in the rat was 1 hour and the plasma clearance (C1 p ) was 0.02 (1 kg −1 ) min −1 . Food does not appear to modify the absolute bioavailability of cyanamide ( F = 93.3 per cent fasted, F = 85.5 per cent unfasted), although it does retard drug absorption.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research