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Relationship between plasma propranolol concentration and dose in young, healthy volunteers
Author(s) -
Dey Mike,
Brisson Jerry,
Davis Gloria,
Enever Robin,
Pray Kathryn,
Zaim Beyhan,
Dvornik Dushan
Publication year - 1986
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510070202
Subject(s) - propranolol , bioavailability , plasma concentration , pharmacokinetics , plasma levels , linear relationship , dose–response relationship , endocrinology , medicine , chemistry , pharmacology , mathematics , statistics
The relationship between dose and bioavailability of propranolol was determined in 12 healthy male subjects. The doses employed were 10, 40, 80 or 160 mg of propanolol HCI given three times daily for 4 days. Daily minimum plasma levels showed that there was no accumulation of the drug. In all subjects, non‐linear relationships were observed between peak plasma level, or area under the plasma concentration‐time curve, and dose. The between subject variation of these parameters was not dose related.