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The non‐linear pharmacokinetics of prednisone and prednisolone. I. Theoretical
Author(s) -
Ferry James J.,
Wagner John G.
Publication year - 1986
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510070111
Subject(s) - prednisolone , prednisone , pharmacokinetics , linear model , mathematics , medicine , pharmacology , statistics
Three simple linear and three simple non‐linear pharmacokinetic models are presented which incorporate the reversible metabolism that occurs between prednisone and prednisolone. Under steady‐state conditions it is possible to not only distinguish between the linear and non‐linear models but also to determine which particular model of each group applies to a given set of data. While the non‐linear conversion of prednisolone to prednisone is important in explaining the pharmacokinetics of prednisone in all three non‐linear models, the same is not true for prednisolone.