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The pharmacokinetics of oral and intravenous prenalterol in young, healthy volunteers
Author(s) -
Clarke A. F.,
Jack D. B.,
Kendall M. J.,
Smith S. R.
Publication year - 1986
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510070107
Subject(s) - pharmacokinetics , dosing , medicine , pharmacology , oral administration , oral dose , anesthesia
The pharmacokinetics of prenalterol in healthy young volunteers after i.v. and oral dosing has been studied. There is evidence of non‐linearity following the i.v. dosing. Evidence of dose‐dependent pharmacokinetics following i.v. dosing has been obtained. The sustained‐release formulation is very effective: almost 12 h were needed to achieve 50 per cent of the total AUC.