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Acetylsalicylic acid metabolites in blood and urine after plain and enteric‐coated tablets
Author(s) -
Montgomery P. R.,
Sitar D. S.
Publication year - 1986
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510070104
Subject(s) - glucuronide , urine , metabolite , chemistry , bioavailability , salicylic acid , pharmacokinetics , chromatography , enteric coating , pharmacology , crossover study , enteric coated , dosage form , medicine , biochemistry , alternative medicine , pathology , placebo
Acetylsalicylic acid (ASA) was administered orally as a single dose to 7 healthy male volunteers as plain or enteric‐coated (Entrophen R ) tablets using a crossover design. Blood and urine samples were collected and analysed for ASA metabolites by high performance liquid chromatography. Labile and stable glucuronide conjugates of salicylic acid (SA) were measured in urine after differential hydrolysis with glucuronidase. Plasma kinetic parameters for the ASA metabolites SA and salicyluric acid were not different for the 2 formulations, apart from the delayed appearance after the enteric‐coated tablets. Total urinary recovery, and recovery of salicyluric acid and the two SA glucuronides were not different, thus confirming the equivalent bioavailability and metabolite profile of the 2 ASA formulations.