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Selective incorporation of asialofetuin into hepatocyte of rat
Author(s) -
Aramaki Yukihiko,
Inaba Asaichi,
Tsuchiya Seishi
Publication year - 1985
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510060405
Subject(s) - kidney , spleen , hepatocyte , biology , pharmacokinetics , lung , microbiology and biotechnology , biochemistry , endocrinology , medicine , pharmacology , immunology , in vitro
Abstract The disposition of asialofetuin was studied in the rat. The radioactivity of 3 H‐asialofetuin administered intravenously disappeared rapidly from the blood. Asialofetuin was specifically and rapidly incorporated into the liver, and had no affinity toward other tissues such as the lung, spleen, heart, and kidney. Asialofetuin accumulated in the lysosomal and microsomal fractions of the rat liver cells immediately after administration, shifted to the low dense fraction (cytosol fraction) with the elapsing of time, and was possibly digested by lysosomes. The elimination of 3 H‐asialofetuin from the liver was fast and the degradates excreted into the bile and urine represented 90 per cent of the dose administered by 180 min following administration. It was suggested that asialofetuin functions as a carrier of drugs to the liver, especially to hepatocytes.