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Confidence intervals for multiple‐dose concentrations in the one‐compartment open model with rapid intravenous injection
Author(s) -
Karpinski K. F.
Publication year - 1985
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510060403
Subject(s) - confidence interval , compartment (ship) , pharmacokinetics , mathematics , medicine , statistics , pharmacology , oceanography , geology
The parameters in a multiple‐dose compartmental model can be estimated from plasma concentration observations after a single dose of drug. These estimates can be used to obtain confidence intervals for the multiple‐dose concentrations. However, since the models are non‐linear functions of the parameters, no exact confidence interval procedures are available. In this paper a conservative interval estimation procedure 1 is applied to the one‐compartment open model with rapid intravenous injection. Also, extended tables required in the estimation procedure are provided.