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Pharmacokinetics of furosemide after three different single oral doses
Author(s) -
Waller Elaine S.,
Massarella Joseph W.,
Tomkiw Motria Sharanevych,
Smith Robert V.,
Doluisio James T.
Publication year - 1985
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510060202
Subject(s) - pharmacokinetics , pharmacology , furosemide , medicine , oral administration , chemistry
Furosemide solution was orally administered to 21 healthy adult males to determine dose proportionality over the dose range used and the reproducibility of disposition following a repeated dose. Furosemide solution was given in doses of 20, 40, and 80mg, with the 40 mg dose repeated once. Blood was collected for 12 hours post‐dose and urine for 24 hours. The maximum plasma concentrations resulting from 20, 40, and 80mg doses were significantly different ( p < 0.05). Dose normalized maximum concentrations for the 20 and 80 mg doses were significantly different ( p < 0.05). Mean time to Cp max was 50 minutes, with no differences observed among doses. Plasma AUCs were significantly different ( p < 0.05) for 20, 40, and 80mg. Dose normalized AUCs were not significantly different. Mean amounts of furosemide in urine ( X u ) were 9.62, 16.7, and 32.0 mg for the 20, 40, and 80 mg doses, respectively. These amounts were significantly different ( p <0. 05); dose normalized amounts were not significantly different. Renal clearances of furosemide following the three doses were not significantly different. Regressions of Cp max , AUC and X u on dose were significant. There were no significant differences in Cp max , t max , AUC or X u for 40 mg given on two separate days. Renal clearance of furosemide was statistically different for 40mg given on two separate days, but the difference was not clinically significant. The pharmacokinetics of furosemide are linear over the dosage range studied. Furosemide 40 mg given on two separate days results in similar disposition parameters.