Relationship between total body clearance of caffeine and urine flow rate in elderly men | Zendy

Trang John M. | Zendy; Blanchard James | Zendy; Conrad Kenneth A. | Zendy; Harrison Gail G. | Zendy

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Relationship between total body clearance of caffeine and urine flow rate in elderly men

Author(s) -

Trang John M.,

Blanchard James,

Conrad Kenneth A.,

Harrison Gail G.

Publication year - 1985

Publication title -

biopharmaceutics and drug disposition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.419

H-Index - 58

eISSN - 1099-081X

pISSN - 0142-2782

DOI - 10.1002/bdd.2510060107

Subject(s) - theophylline , theobromine , caffeine , paraxanthine , urine , chemistry , medicine , endocrinology , metabolism , biochemistry , cyp1a2 , cytochrome p450

The total body clearance (CL), renal clearance (CL R ), and nonrenal clearance (CL NR ) of caffeine from plasma were determined following the intravenous administration of caffeine (4mgkg −1 ) to ten healthy men (aged 66–86 years) on three separate occasions. Positive correlations were observed between CL and urine flow rate (UFR), between CL R and UFR, and between CL NR and UFR ( r = 0.8947, p = 0.0002; r = 0.8832, p = 0.0003; and r = 0.8920, p = 0.0002, respectively). Previous studies have established similar relationships between CL R and UFR for caffeine and its initial dimethylxanthine metabolites; theophylline, theobromine, and paraxanthine. A relationship between CL and UFR has not been reported previously.

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