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Relationship between total body clearance of caffeine and urine flow rate in elderly men
Author(s) -
Trang John M.,
Blanchard James,
Conrad Kenneth A.,
Harrison Gail G.
Publication year - 1985
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510060107
Subject(s) - theophylline , theobromine , caffeine , paraxanthine , urine , chemistry , medicine , endocrinology , metabolism , biochemistry , cyp1a2 , cytochrome p450
The total body clearance (CL), renal clearance (CL R ), and nonrenal clearance (CL NR ) of caffeine from plasma were determined following the intravenous administration of caffeine (4mgkg −1 ) to ten healthy men (aged 66–86 years) on three separate occasions. Positive correlations were observed between CL and urine flow rate (UFR), between CL R and UFR, and between CL NR and UFR ( r = 0.8947, p = 0.0002; r = 0.8832, p = 0.0003; and r = 0.8920, p = 0.0002, respectively). Previous studies have established similar relationships between CL R and UFR for caffeine and its initial dimethylxanthine metabolites; theophylline, theobromine, and paraxanthine. A relationship between CL and UFR has not been reported previously.