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Distribution of sodium valproate and gaba metabolism in cns of the rat
Author(s) -
Hariton Claude,
Ciesielski Lucien,
Simler Simone,
Valli Marc,
Jadot Guy,
Gobaille Serge,
Mesdjian Edouard,
Mandel Paul
Publication year - 1984
Publication title -
biopharmaceutics and drug disposition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.419
H-Index - 58
eISSN - 1099-081X
pISSN - 0142-2782
DOI - 10.1002/bdd.2510050412
Subject(s) - distribution (mathematics) , hypothalamus , endocrinology , metabolism , medicine , sodium , chemistry , olfactory bulb , pharmacology , central nervous system , biology , mathematics , mathematical analysis , organic chemistry
The distribution of VPA has been investigated in several brain areas of the rat, and GABA increases were measured. A biphasic exponential decay was observed for VPA; the slowest decrease was noted in the olfactory bulbs and in the hypothalamus where GAD and GABA‐T activities were the highest. The data may be correlated with the prolonged effect of VPA in these areas.